Tobacco leaf production is increasing across Africa, with Mozambique ranking among the continent’s top five producers. This growth is raising concerns with the World Health Organization (WHO), which highlights the detrimental effects of tobacco farming. These impacts span health risks, environmental damage, and threats to the livelihoods of farmers involved in cultivation. The recent analysis indicates a concerning trend, as increased production correlates with higher rates of tobacco-related illnesses and deforestation. The WHO is urging for increased awareness and sustainable agricultural alternatives to mitigate these growing problems. The situation demands attention to protect both public health and the African environment.