President Cyril Ramaphosa has urged African nations to reinforce their pandemic preparedness following recent Ebola outbreaks in the Democratic Republic of Congo and Uganda. He emphasized that these outbreaks serve as a stark reminder of the continent’s vulnerability to infectious diseases and the critical need for robust health security systems. Ramaphosa highlighted the importance of investing in infrastructure, personnel, and surveillance capabilities to effectively prevent, detect, and respond to future health crises. He stressed that a coordinated continental approach is essential for safeguarding public health and mitigating the socio-economic impacts of pandemics. The outbreaks underscore existing weaknesses in healthcare systems and the necessity for increased international collaboration to support African nations. Strengthening health security is now positioned as a key priority for the continent’s development agenda.