New research suggests a passage in Homer’s *Odyssey* describing the sorceress Circe and her island may allude to the use of a psychedelic drug, potentially ergot, and a possible antidote. Scholars have long debated the location of Circe’s island, now believed by some to be in Lazio, Italy. The analysis focuses on descriptions of food and drink offered by Circe that induced forgetfulness in Odysseus’s men. Researchers propose these effects align with ergot poisoning, a fungus that grows on grains and can cause hallucinations and memory loss. Furthermore, the text details a *moly* herb given to Odysseus as protection, which is theorized to have contained compounds countering ergot’s effects. This interpretation offers a novel perspective on the ancient Greek text, linking it to historical knowledge of psychoactive substances and their mitigation. The study doesn’t definitively prove drug use, but presents a compelling argument based on textual analysis and botanical possibilities.