A medical plane carrying six people has disappeared off the coast of North Carolina, United States, prompting a large-scale search and rescue operation. The aircraft, a Cessna 402, was en route from Puerto Rico to Myrtle Beach, South Carolina when it lost contact with air traffic control Thursday evening. The US Coast Guard is leading the search efforts, covering a wide area of the Atlantic Ocean. Initial reports suggest challenging weather conditions may have contributed to the disappearance. Authorities have not yet released details about the individuals on board, but confirm they were involved in a medical transport. The search continues with air and sea assets deployed, focusing on locating any debris or signs of the aircraft. Family members of those on board have been notified and are awaiting updates as the operation progresses.