Joana Lamego, currently the Head of Strategic Research Development at the Champalimaud Foundation, describes herself as a “retired scientist.” In a recent discussion, Lamego explored the complexities of transitioning beyond successful scientific research. The conversation delved into the challenges of moving from a comfortable position of achievement to new roles. She addressed themes of science, management, and personal ambition. Lamego’s reflections offer insight into the difficulties faced when navigating career shifts after establishing expertise in a specific field. The discussion highlights the less-discussed aspects of professional growth beyond initial success. Her perspective provides a nuanced view of leadership and the pursuit of continued development.