Data from the Hellenic Integrated Health Information System (HIDIKA) reveals that 4.7 million Greek citizens receive at least one antibiotic prescription annually. This figure underscores Greece’s continued position as a leading country in Europe for antimicrobial consumption. The high rate of antibiotic use raises concerns about growing antimicrobial resistance. Experts attribute the overuse to factors including patient demand and prescribing practices. This widespread consumption poses a significant public health risk, potentially diminishing the effectiveness of these crucial medications. Authorities are working to address the issue through awareness campaigns and stricter prescription guidelines, but challenges remain in curbing the trend. The data highlights the urgent need for responsible antibiotic stewardship in Greece.