Africa is preparing for significant weather disruptions as the El Niño phenomenon strengthens. The continent faces a critical period requiring proactive measures to build resilience against increasing climate variability. The success of these preparations will directly impact future harvests across Africa, potentially affecting food security. Livelihoods are also at risk, particularly for communities reliant on agriculture and natural resources. Furthermore, health systems in Africa may be strained by climate-sensitive diseases and emergencies. Effective leadership and community-level responses are now essential to mitigate the worst effects of El Niño and safeguard the well-being of populations across Africa.