Residents of Busia Municipality, Uganda are facing a growing bed bug infestation, reporting difficulty sleeping due to the pests. The issue is compounded by the insects’ increasing resistance to common chemical treatments. Locals have expressed their concerns to Uganda Radio Network, detailing the nuisance and disruption to their daily lives. The outbreak is currently affecting numerous villages within the municipality. Residents are actively seeking assistance to address the problem and regain peaceful nights. The situation highlights a potential public health concern and a need for more effective pest control measures within the region. Further investigation is needed to determine the scale of the outbreak and source of the resistant bed bugs.