Indonesia hosted a high-level forum with ASEAN member states focused on bolstering the region’s capacity to develop, produce, and access vaccines and medical countermeasures. The initiative aims to strengthen the entire pharmaceutical ecosystem, encompassing research, development, manufacturing, and distribution. Discussions centered on preparing for future pandemics and reducing reliance on external sources for critical medical supplies. Participants emphasized the importance of regional collaboration and knowledge sharing to enhance health security. The forum addressed challenges related to funding, technology transfer, and regulatory harmonization. Ultimately, the goal is to create a more self-sufficient and resilient ASEAN health infrastructure capable of responding effectively to emerging health threats. This effort signifies a proactive approach to pandemic preparedness within the region.