The Africa Centres for Disease Control and Prevention (Africa CDC) has released an operational toolkit aimed at preventing, diagnosing, and managing Hepatitis B across the continent. This initiative signifies a crucial step towards strengthening Africa’s public health infrastructure and reducing the burden of the disease. The toolkit provides comprehensive guidance for implementing effective hepatitis programs at national and local levels. It emphasizes the importance of widespread vaccination, early detection through testing, and accessible treatment options. The launch underscores Africa CDC’s commitment to achieving universal health coverage and bolstering the continent's "health sovereignty" – its capacity to independently address its own health challenges. By providing locally-relevant resources, the toolkit aims to empower African nations to take ownership of their hepatitis response. This action represents a proactive approach to fighting a major public health threat and improving the health outcomes for millions of Africans.